Screening the Yeast “Disruptome” for Mutants Affecting Resistance to the Immunosuppressive Drug, Mycophenolic Acid
نویسندگان
چکیده
منابع مشابه
Screening the yeast "disruptome" for mutants affecting resistance to the immunosuppressive drug, mycophenolic acid.
The immunosuppressive drug mycophenolic acid (MPA) is a potent and specific inhibitor of IMP dehydrogenase, the first committed step of GMP synthesis. A screen for yeast genes affecting MPA sensitivity, when overexpressed, allowed us to identify two genes, IMD2 and TPO1, encoding a homologue of IMP dehydrogenase and a vacuolar pump, respectively. In parallel, 4787 yeast strains, each carrying a...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2002
ISSN: 0021-9258
DOI: 10.1074/jbc.m111433200